Current Cytogenetic Methods for Detecting Exposure and Effects of Mutagens and Carcinogens
نویسندگان
چکیده
منابع مشابه
Current cytogenetic methods for detecting exposure and effects of mutagens and carcinogens.
Most mutagens and genotoxic carcinogens are efficient inducers of chromosomal alterations in exposed cells. Two important classes of aberrations, namely structural and numerical, are recognized and both types of aberrations are associated with congenital abnormalities and neoplasia in humans. These alterations can be easily detected and quantified in human peripheral blood lymphocytes. Conventi...
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15 صفحه اولGenetic and Epigenetic Effects of Environmental Mutagens and Carcinogens
1Department of Health Sciences, University of Genoa, Via Antonio Pastore 1, 16132 Genoa, Italy 2Toxicology Institute, Preventive Medical College, Third Military Medical University, Chongqing 400038, China 3Department of Genetics and Evolutionary Biology, Institute of Bioscience, University of São Paulo, 05508-090 São Paulo, SP, Brazil 4Laboratory of Toxicology UT-BIORAD, ENEA, CR Casaccia, Via ...
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Rapid detection of mutagens and carcinogens.
SUMMARY Bacteria deficient in DNA polymerase are much more sensitive to agents that alter cellular DNA than the parent strain from which they were derived. Advantage can be taken of this greater sensitivity to screen for potential mutagens and carcinogens.
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1996
ISSN: 0091-6765
DOI: 10.2307/3432801